Lion’s Mane and the liver: how the mushroom helps restore and protect it

6 May 2025

Liver Regeneration with the Help of Lion’s Mane Mushroom

The liver is the body’s main filter. It is one of the most vital organs, involved in metabolism, detoxification, protein synthesis, nutrient storage, digestion, blood sugar regulation, and over 500 other essential functions. However, the daily burden of poor diet, stress, alcohol, and medications eventually wears it down. That’s why it is so important to find natural remedies that can support or even restore its function. And this is where Lion’s Mane mushroom (Hericium erinaceus) comes in — a healing mushroom with scientifically proven ability to protect and regenerate the liver.

Read more about the properties of this mushroom in the article: Properties of Lion’s Mane mushroom

Research: How the Mushroom Protects the Liver from Alcohol

In 2014, a team of Chinese researchers conducted an experiment (Hao L. et al., "Protective Effect of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice,” 2015. Evidence-Based Complementary and Alternative Medicine, PMID: 25960751), which confirmed that Lion’s Mane significantly reduces alcohol-induced liver damage. What’s more, this effect was verified using specific biomarkers.

Alcohol remains one of the main causes of liver damage worldwide. Even short-term binge drinking can trigger acute inflammation and damage liver cells. In the experiment, researchers simulated this scenario in mice by administering high doses of ethanol. Some of the animals also received Lion’s Mane extract. The results showed clear improvement — the mushroom protected the liver from inflammation, damage, and oxidative stress.

In the group treated with Lion’s Mane, the following improvements were observed:

ALT (a marker of liver damage) decreased by 40%
AST (an enzyme indicating cellular inflammation) decreased by 35%
MDA (a marker of oxidative stress) decreased by 30%
TAOS (total antioxidant status of the liver) increased by 17%, indicating improved ability to neutralize toxins

Additionally, histological analysis of the liver tissue (microscopic examination) showed that the livers of the treated animals maintained structural integrity and had fewer inflamed areas.

Also check out Auricularia auricula-judae — a mushroom known to help with liver recovery:Auricularia auricula: Supporting the Liver after Alcohol-Related Damage

Key Bioactive Compounds in Lion’s Mane:

♦ Antioxidants – protect liver cells from free radicals (unstable molecules that damage DNA and membranes)
♦ Polysaccharides – complex carbohydrates that support the immune system and have anti-inflammatory properties
♦ Terpenoids (erinacines) – small molecules that can penetrate cells and influence intracellular processes, including inflammation reduction

These compounds work together to reduce damage, suppress inflammation, and activate the liver’s natural defense mechanisms.

Research: Combating Inflammation

In another 2016 study (Cui F. et al., “Protective Effects of Extracellular and Intracellular Polysaccharides on Hepatotoxicity by Hericium erinaceus SG-02”, Curr Microbiol, PMID: 27262461), scientists focused on liver inflammation. They studied the protective effects of Lion’s Mane polysaccharides in a mouse model of liver toxicity mimicking human conditions. The results were remarkable.

Thanks to Lion’s Mane supplementation, the following improvements were observed:

♦ AST – decreased by 47%
♦ ALT – decreased by 36%
♦ Triglycerides – decreased by 40%
♦ Albumin – restored to normal levels (this is the main protein produced by the liver)

There was also a reduction in signs of oxidative stress in liver tissues, while antioxidant enzymes (catalase, superoxide dismutase) were activated. This means the mushroom doesn’t just relieve symptoms, but actually triggers the natural regeneration of liver cells.

Also read: How Reishi Mushroom Helps Reduce the Harm of MSG (E621)

Benefits of Lion’s Mane for Liver Health:

Natural protection from toxins (including alcohol)
Cellular-level inflammation reduction
Enhanced antioxidant defenses
Restoration of liver structure and function
Stabilization of liver-related blood enzymes
Bonus: also supports the nervous system and digestive tract

Even if you don’t drink much alcohol, your liver is exposed daily to toxins from food, medications, and the environment. Lion’s Mane is not a miracle cure, but it’s a powerful ally in maintaining one of your most important organs.

Regular use of high-quality Lion’s Mane extract can become part of a liver disease prevention strategy or help during recovery from liver overload.

This information is provided for informational purposes only and is not medical advice. Consult your doctor before taking any supplements.

In our shop, you’ll find premium-quality Lion’s Mane extracts (Hericium erinaceus), standardized for active compounds. And most importantly — we’ll guide you on how and in what dosage to take it so it truly benefits your health.

Support your well-being naturally and protect yourself from serious diseases before they start!

Order high-quality Lion’s Mane extract from our website!

❓ Frequently Asked Questions about Lion’s Mane and Liver Health

1. Can Lion’s Mane really help the liver?

Yes, studies show that Lion’s Mane extracts reduce inflammation, enhance antioxidant defenses, and support regeneration of liver cells after toxic damage.

2. How exactly does it protect the liver?

Thanks to its polysaccharides, antioxidants, and erinacines, the mushroom reduces oxidative stress, lowers ALT/AST enzymes, and activates natural healing mechanisms.

3. Can it be combined with liver medications?

Yes, but it’s best to consult a doctor. Lion’s Mane has a gentle, natural action and usually does not interfere with medications.

4. How long does it take to see effects?

Initial results may be noticeable within 2–4 weeks of regular use, especially when taking a high-quality extract with a strong polysaccharide content.

5. Is it suitable for people without liver issues?

Absolutely. Lion’s Mane is an excellent preventive supplement — supporting the liver during chronic stress, medication use, or exposure to environmental toxins.

For each client individually, we draw up instructions according to his indicators and requests

Monthly Course: