How Reishi mushroom helps reduce the harm caused by monosodium glutamate (E621)

29 April 2025

How Reishi Mushroom Helps Reduce the Harm of Monosodium Glutamate (E621)

Reishi (Ganoderma lucidum) is one of the most well-known medicinal mushrooms in the world. In China, it has long been called the "mushroom of immortality", while in Japan it is known as Mannentake, which translates to "mushroom of ten thousand years." Other common names include Lingzhi, varnished conk, and Ganoderma.

Who doesn’t enjoy crunching on chips with friends, snacking on the go, or indulging in a tasty treat in front of the TV? But have you ever thought about the price your body pays for such pleasure? One of the main enemies to health in these products is monosodium glutamate (E621).

Why is Monosodium Glutamate (E621) Dangerous?

This popular flavor enhancer is found not only in snacks, sauces, and seasonings but also in processed foods, canned goods, meat products, sweets, and even dietary supplements and baby formulas. However, with regular consumption, it can:

increase estrogen levels in the blood, potentially causing hormonal imbalances;
lead to cholesterol accumulation in the body, contributing to cardiovascular diseases;
negatively affect the immune system by reducing white blood cell counts;
provoke obesity and metabolic disorders;
damage and structurally alter the kidneys and liver;
cause oxidative stress in cells, leading to their damage.

(Kinash O. V. et al., 2021, DOI: 10.29254/2077-4214-2021-3-161-49-52), (Ofodile Lauretta Nwanneka et al., 2020, https://doi.org/10.21315/mjps2020.18.2.4)

By not controlling our intake of foods containing E621, we create the perfect environment for chronic diseases to develop. Monosodium glutamate can disrupt the nervous system, cause headaches, fatigue, and allergic reactions.

Also recommended: Lion’s Mane Mushroom in Fighting Cardiovascular Diseases and Cholesterol.

How Reishi Mushroom Helps Combat the Effects of E621

According to a study conducted on rats in 2020, the extract of Reishi mushroom (Ganoderma lucidum), thanks to its powerful medicinal properties, can neutralize the damage caused by monosodium glutamate (Ofodile Lauretta Nwanneka et al., 2020).

Study Results on Rats

In the study, one group of animals consumed monosodium glutamate together with Reishi for 60 days. Compared to the control group that did not receive Reishi, the results were impressive:

elevated estrogen levels decreased by 41%;
hemoglobin levels improved by 30%;
cholesterol levels returned to normal;
the number of red and white blood cells stabilized, almost matching healthy animals.

Another group of rats consumed monosodium glutamate for 30 days and then received Reishi extract. Significant improvements were also observed in this group, although the effects were less pronounced. This indicates that it is better to act preventively rather than wait for complications.

Also recommended: How Reishi Mushroom Helps with Hypertension: Scientific Facts and Health Benefits.

Benefits of Regular Reishi Consumption

If you can't imagine your life without delicious — but not always healthy — foods, Reishi mushroom can become your perfect ally in the battle for your health! Regular consumption can help:

protect your body from the harmful effects of monosodium glutamate;
strengthen your immune system;
reduce the risk of cardiovascular diseases;
improve liver function.

Learn more: A Healthy Gut Is the Key to a Strong Immune System!

Where to Buy High-Quality Reishi Extract

Don't delay your health care — its quality and longevity depend on it.

Order high-quality Reishi extract from our store — support your body today! Write to us, and we will help you choose the best form and dosage specifically for your needs.

This information is provided for educational purposes only and does not constitute medical advice. Consult a healthcare professional before taking any supplements.

Frequently Asked Questions About Reishi and Monosodium Glutamate

1. Why is monosodium glutamate harmful to the body?

Monosodium glutamate (E621) can cause hormonal imbalances, increase cholesterol levels, impair liver and kidney function, and negatively affect the nervous system.

2. Can Reishi mushroom neutralize the harm of monosodium glutamate?

Yes, animal studies have shown that Reishi extract reduces estrogen and cholesterol levels, improves blood composition, and decreases organ damage.

3. How long should Reishi be taken to notice an effect?

The best results in studies were observed with simultaneous intake with monosodium glutamate for 60 days. However, Reishi also showed beneficial effects when taken after damage had already occurred, although the process was slower.