Lion's mane mushroom in the fight against cardiovascular disease and cholesterol

How does it work?

Scientists have found that Hericium erinaceus (lion's mane mushroom) has very high anti-oxidant activity against LDL oxidation. LDL is the “bad” cholesterol that can accumulate in the arteries and lead to heart disease.

The mushroom is able to reduce the formation of oxidized LDL, and decrease the amount of substances that react to oxidation. This means that it may help prevent the formation of “bad” cholesterol in the body.

In addition, it has been found that Hericium erinaceus inhibits (or stops) the activity of a key enzyme responsible for cholesterol production in the body.

What does this mean for you?

These findings suggest that Hericium erinaceus may be a powerful tool for supporting heart and vascular health. While it is not a substitute for a healthy lifestyle or treatment prescribed by your doctor, it may be a useful addition to your daily diet.

Article title:

The Effect on In Vitro Inhibition of LDL Oxidation and HMG Co-A Reductase Activity of Rare Ethanol and Ethyl Acetate Fractions of Hericium erinaceus (Bull.) Persoon (Lion's Mane Mushroom)

Published in:

BioMed Research International, 2014


Mohammad Azizur Rahman, Nurlida Abdullah, and Norhanizah Aminuddin


Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia


  • Antioxidant and hypocholesterolemic properties of lion's mane mushroom
  • The effect of different solvents on the extraction of bioactive compounds from the mushroom
  • The mechanisms by which the mushroom may prevent LDL oxidation and inhibit the activity of HMG Co-A reductase, a key enzyme in cholesterol synthesis

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