Antitumor Activity of Cordyceps militaris against Hepatitis C Virus-Infected Hepatocellular Carcinoma Cells

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Hepatitis C virus (HCV) often causes chronic hepatitis, which leads to liver cirrhosis and the development of HCC.

In 2015, the results of a study were published in the Journal of Microbiology in which scientists from South Korea investigated the antitumor activity of ethanol extract of Cordyceps militaris (CME) on human hepatocellular carcinoma cells, including those infected with HCV.

The studies showed that CME has potent antitumor activity against HCV-infected human hepatocellular carcinoma cells. Cordyceps suppresses the growth and proliferation of cancer cells, induces their death through apoptosis (programmed cell death), and reduces their size.

It was found that CME:

  • Effectively kills cancer cells, reducing their viability by 75-100%.
  • Triggers the apoptosis process - natural programmed cell death. Depending on the dose, it accumulates the early stage of apoptosis up to 6.78% of cancer cells.
  • Increases the number of special proteins (Bim, Bax, caspase-3, and caspase-9). These proteins are responsible for the activation of apoptosis and the death of cancer cells.
  • Reduces the number of viral proteins (Core and NS3) in cells infected with the hepatitis C virus. That is, it has an antiviral effect.
  • Suppresses tumor growth and promotes their size reduction compared to the control group.

The results of the study suggest the feasibility of using CME for the prevention and to enhance the effectiveness of standard HCC treatment methods, especially those associated with HCV.

Cordyceps militaris has immunomodulatory, anti-inflammatory, antitumor, and antiviral effects, making it beneficial for your liver and protecting against the development of cancer. Take care of your health, take care of your loved ones, and take a course of Cordyceps militaris, because a healthy liver is the key to the health of the whole body!

The article is based on a published scientific study in the Journal of Microbiology (2015) 53, 7, 468. For our regular customers, we can provide a printout of the translation of the article upon request.

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