Complex for fighting oncology and supporting chemotherapy extra

The “Extra” mushroom extract complex for body support during oncology and chemotherapy combines five standardized extracts: Reishi (Ganoderma lucidum), Shiitake (Lentinula edodes), Turkey Tail (Trametes versicolor), Chaga (Inonotus obliquus), and Lion’s Mane mushroom (Hericium erinaceus).

The formula brings together mushrooms whose bioactive substances are studied in relation to immune regulation, antitumor immune response, apoptosis, control of cell proliferation, angiogenesis, and metastatic processes. Antioxidant protection, nervous system support, and the body’s natural recovery processes form a separate area of focus.

Scientific interest in these mushrooms is not limited to immunomodulation. In experimental studies, their extracts and individual components have demonstrated antiproliferative, pro-apoptotic, and antioxidant activity, while certain mushroom polysaccharides also have clinical studies on their use as auxiliary components in oncology.

The complex is designed for periods of high load on the body, when it is important to support the immune system, cellular defense mechanisms, antioxidant balance, the nervous system, and recovery processes at the same time.

Data on the antitumor properties of individual components have been obtained in studies of different levels – from cell and animal models to individual clinical studies.

Active components of the complex

The biological activity of the complex is based on β-glucans, polysaccharides, lentinan, PSK and PSP, triterpenoids, phenolic compounds, erinacines, and other natural mushroom components. They differ in structure and mechanisms of action, which makes it possible to cover different branches of the immune and cellular response within one formula.

β-glucans
The main group of bioactive polysaccharides in medicinal mushrooms. They interact with receptors of macrophages, dendritic cells, and other cells of innate immunity, participating in the regulation of the body’s protective response.

Lentinan
A Shiitake β-glucan with a large scientific base. Its biological activity is primarily associated with the regulation of cellular immunity; lentinan has also been studied as an auxiliary component alongside standard anticancer therapy.

PSK and PSP
Polysaccharide-protein complexes of Turkey Tail. They influence the activity of NK cells, macrophages, and T lymphocytes, while PSK has its own history of clinical use and research as an adjuvant component in oncology.

Triterpenoids
Characteristic bioactive compounds of Reishi and Chaga. Experimental studies investigate their antioxidant properties and their influence on cellular mechanisms associated with proliferation, apoptosis, and the inflammatory response.

Chaga phenolic compounds
Participate in antioxidant protection and neutralization of excess reactive oxygen species, complementing the action of mushroom polysaccharides.

Erinacines
Neuroactive compounds of Lion’s Mane mushroom associated with NGF stimulation and support of neuroplasticity. At the same time, the antitumor activity of Hericium erinaceus is not limited to erinacines: in preclinical studies, polysaccharide-protein complexes and other components of the mushroom have also demonstrated such activity.

Main properties of the complex

Course-based intake is aimed at:

☘️ supporting normal immune system function and cellular immune response;

☘️ supporting the activity of NK cells, macrophages, and T lymphocytes;

☘️ providing the body with different types of mushroom β-glucans and polysaccharides;

☘️ antioxidant protection of cells;

☘️ supporting natural cellular mechanisms of protection and recovery;

☘️ supporting the body during periods of high physiological load;

☘️ supporting the nervous system and neuroplasticity;

☘️ supporting memory and cognitive functions during periods of exhaustion;

☘️ supporting the liver and gut;

☘️ additional nutritional support for the body during main treatment – after agreement with a doctor.

Why five mushrooms are combined in the complex

The combination of Reishi, Shiitake, Turkey Tail, Chaga, and Lion’s Mane mushroom makes it possible to bring together different mechanisms of biological activity in one complex.

Reishi supports regulation of the immune response and the body’s natural defense mechanisms. Shiitake, due to lentinan and other β-glucans, influences cellular immune response. Turkey Tail contains polysaccharide complexes known for their immunomodulatory activity and research in oncology. Chaga adds antioxidant and cellular protection due to polysaccharides, triterpenoids, and phenolic compounds. Lion’s Mane mushroom combines nervous system support with immunomodulatory properties, while its extracts and individual components have demonstrated effects on proliferation, apoptosis, and metastatic processes in preclinical studies.

In this formula, the mushrooms do not duplicate each other as sources of β-glucans: each adds its own bioactive substances and mechanisms of action. This makes it possible to simultaneously cover immune regulation, cellular defense mechanisms, antioxidant protection, the nervous system, and the body’s recovery processes – areas that are especially relevant during periods of high load and recovery.

Buy a mushroom extract complex for oncology support in Ukraine

The complex of standardized extracts of Reishi, Shiitake, Turkey Tail, Chaga, and Lion’s Mane mushroom is available for online ordering with delivery across Ukraine and international shipping.

The complex is used as an additional element of body support and does not replace chemotherapy, radiation therapy, immunotherapy, targeted therapy, hormone therapy, or any other anticancer therapy.

The complex is most often chosen:

• for additional body support in oncological diseases;
• during chemotherapy – after agreement with a doctor;
• between courses of anticancer therapy;
• during recovery after completing treatment;
• to support the immune system;
• to support the natural antitumor immune response;
• during high physiological load on the body;
• for additional antioxidant support;
• during physical and psycho-emotional exhaustion;
• to support the nervous system and cognitive functions;
• to support the liver and gut;
• by people who want to receive different groups of mushroom polysaccharides and β-glucans within one course.

In case of an oncological disease, the intake of any dietary supplements during active treatment must be agreed with an oncologist, since compatibility depends on the specific medications and therapy regimen.

Sohretoglu D. et al. (2018). Ganoderma lucidum Polysaccharides as An Anti-cancer Agent – analyzed Reishi polysaccharides and their effects on the immune response, apoptosis, angiogenesis, and other cellular mechanisms associated with tumor development.

Wang J. et al. (2017). A polysaccharide from Lentinus edodes inhibits human colon cancer cell proliferation and suppresses tumor growth in athymic nude mice – investigated the Shiitake polysaccharide SLNT in relation to colorectal cancer cell proliferation and apoptosis, as well as tumor growth in an animal model.

Torkelson C.J. et al. (2012). Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer – in a phase I clinical study, evaluated the safety and immunological effects of oral Trametes versicolor use in women after completing radiation therapy for breast cancer.

Chung M.J. et al. (2010) Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells — investigated Chaga components in relation to tumor cell proliferation, apoptosis, and tumor growth in cellular and animal models.

Younis A.M. (2017) Anticancer potential of Hericium erinaceus extracts against particular human cancer cell lines — investigated aqueous and other Hericium erinaceus extracts on liver cancer HepG2, colon cancer HCT116, cervical cancer HeLa, and breast cancer MCF-7 cells; the aqueous extract of lyophilized fruiting bodies showed the highest antiproliferative activity.

Winder M. et al. (2021) The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology — summarized data on the immunomodulatory and potential antitumor activity of Hericium erinaceus and Trametes versicolor and their possible use as auxiliary components in oncology.

ℹ️ The cited studies describe biological mechanisms and are not medical recommendations.

Course: 1 month.

The complex contains five separate standardized mushroom extracts – Reishi, Shiitake, Turkey Tail, Chaga, and Lion’s Mane mushroom.

The intake protocol is selected individually, taking into account the main treatment, overall condition, and tolerance of the components.

An individual intake protocol is provided with the order.

During chemotherapy, radiation therapy, targeted therapy, hormone therapy, or immunotherapy, the timing of mushroom extract intake and their compatibility with the specific treatment regimen must be agreed with a doctor in advance.

Standardized extracts are used for the complex:

• Reishi (Ganoderma lucidum);
• Shiitake (Lentinula edodes);
• Turkey Tail (Trametes versicolor);
• Chaga (Inonotus obliquus);
• Lion’s Mane mushroom (Hericium erinaceus).

The extracts are standardized for β-glucans — 20% and polysaccharides — 50%, while Hericium erinaceus additionally contains erinacine A — 3%.

The quality of the raw material, moisture content, absence of foreign impurities, and compliance with sanitary standards are controlled.

We work only with verified raw material and provide transparent information about the composition and standardization of the products.

Storage conditions

Store in a dry, dark place.

Avoid moisture, high temperature, and direct sunlight.

Keep out of reach of children.

Before starting intake, it is advisable to agree the complex with a doctor:

• during chemotherapy;
• during immunotherapy;
• during targeted or hormone therapy;
• during radiation therapy;
• before surgery;
• when taking anticoagulants or antiplatelet agents;
• when using immunosuppressive medications;
• in case of autoimmune diseases;
• in case of pronounced liver or kidney function disorders.

It is also not recommended to use without consulting a specialist for children under 18 years old, pregnant women and women during lactation, as well as in case of individual sensitivity or allergy to mushrooms.

Individual body response

At the beginning of intake, the following may occur:

• stomach discomfort or sensitivity;
• changes in stool;
• nausea;
• headache;
• individual sensitivity to certain components.

In case of discomfort, the intake protocol should be reviewed and, if necessary, discussed with a specialist.

Important: the complex is intended for additional body support and does not replace treatment prescribed by an oncologist.